You can do nearly all of the work necessary to properly structure and prepare a document for accessibility directly in InDesign, leaving just a final check to complete in Acrobat.
https://www.adobe.com/accessibility/products/indesign.html
1. Use paragraph styles
Consistent use of InDesign paragraph styles throughout a document is critical for efficiently and successfully exporting the content to PDF. Base styles on their hierarchical structure (main headline, secondary headings, subheading, and so on) and apply them appropriately to paragraphs according to their hierarchical role in the document.
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